The Effect of n-3 Fatty Acids on Lipids and Haemostasis in Patients with Type lla and Type IV Hyperlipidaemia

E Berg Schmidt; E Ernst; K Varming; J O Pedersen; J Dyerberg

doi:10.1055/s-0038-1646906

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1989; 62(02): 797-801
DOI: 10.1055/s-0038-1646906

Original Article

Schattauer GmbH Stuttgart

The Effect of n-3 Fatty Acids on Lipids and Haemostasis in Patients with Type lla and Type IV Hyperlipidaemia

E Berg Schmidt

¹The Department of Clinical Chemistry, Aalborg Hospital, Aalborg, Denmark

³The Department of Geriatrics, Aalborg Hospital, Aalborg, Denmark

,

E Ernst

¹The Department of Clinical Chemistry, Aalborg Hospital, Aalborg, Denmark

,

K Varming

²The Department of Clinical Immunology, Aalborg Hospital, Aalborg, Denmark

,

J O Pedersen

²The Department of Clinical Immunology, Aalborg Hospital, Aalborg, Denmark

,

J Dyerberg

¹The Department of Clinical Chemistry, Aalborg Hospital, Aalborg, Denmark

› Author Affiliations

Abstract

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Summary

Plasma lipids and haemostasis were investigated in 17 patients with hyperlipidaemia before and after 6 weeks supplementation with 6 g n-3 fatty acids. Nine of the patients had type IIa and 8 had type IV hyperlipidaemia. No effect on plasma cholesterol, LDL- or HDL-cholesterol were seen, but plasma triglycerides decreased after n-3 supplementation. Apolipoprotein B increased and apolipoprotein A₁ decreased after the oil supplement. The bleeding time was prolonged, but platelet aggregation was unaltered by n-3 fatty acids. Protein C activity increased in type II a and decreased in type IV after the supplement. Fibrinolysis was markedly depressed while von Willebrand factor antigen was reduced after intake of n-3 fatty acids.

Keywords

n-3 fatty acids - Fish oil - Lipids - Haemostasis - Fibrinolysis

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References

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